the 750 carb also has float bowls that store enough fuel to cover you in the event that fuel sloshes away from the tank pickup while cornering etc., which is a luxury you don't have in a high pressure EFI system... Probably fine if you never have less than 1/3 of a tank though...
Historically solved with surge tanks and so forth, but you'd be doing me a big favor if you tried out a holley hyrdamat in a stock tank and posted results