[hatzie]

Holley made a carb for the 1V intakes that made the 250 in my Nova pretty healthy for a six.
If you have a single 2bbl intake you're not limited to the Rochester 2G. The Rochester 2Gs are bloody easy to work on but they tend to be fuel hogs.
The Jeep guys like the Motorcraft 2150 2 bbl on the 258 AMC. I don't have anything bad to say about that carb. It made my Eagle run like it should've when it came off the line in Kenosha. But again they're fuel hungry.
If you want the performance of a 2bbl without the fuel consumption of the un-refined Holley, Rochester, or Motorcraft look up Weber progressive 2bbl carbs. There's some setup in picking out jets etc but they're easier than a modern Chinese Carter AFB.

If you're a glutton for punishment you can run a Zenith progressive 2bbl. The Zenith is probably difficult to find and more difficult to source parts for now and it was a royal PITA to setup correctly but once properly matched to the engine they woke up the 4 and 6 cylinder VW and GM engines I used them on. They were as stable and un-fiddly as the Rochester Quadrajet once they were tuned to match the engine.

Another option is to get a Clifford or Offenhauser 4bbl intake and run a 360-390cfm Holley. Any more than that will be too much carb for the engine. Be prepared for sticker shock on the intakes.

If you run the 4bbl you'll want to keep the primaries and secondaries parallel to the cylinders. If you run em perpendicular to the cylinders you'll have fuel balance issues... front cylinders lean and rear rich kinda stuff. The throttle linkage takes some work on parallel barrel setups but unbalanced fueling from Perpendicular primaries & secondaries will not make the fun last for long.

Another option that's high on cool points but a lot more expensive and difficult to setup is multi-carbs... 1x3, 2x2, or 2x3. Balancing three 1bbl carbs or a pair of or triple 2bbl carbs takes some time and patience. Not to mention fabricating the throttle linkages and the cost of or time to build the custom intake. If you can find a multi-carb intake from the 50's or 60's you'll likely end up paying for it.

Or you can play with mechanical or electronic MPFI. I thought about using Bosch mechanical CIS from a Benz or Audi six on my 258 and a 292 I had in one of my trucks but i put a Motorcraft 2150 on the 258 and a Zenith on the 292.