I recently upgraded my stock 6 lug front disc/caliper setup (running 15x6 steelies) with Wilwood D52 calipers, slotted/drilled 6 lug rotors and stainless braided brake hoses. Yes, it made a noticeable difference with both firmer pedal feel and improved stopping performance over the stock setup.
Slotted/drilled 6 lug rotors:
https://www.classicchevy.com/1960-19...-876986-1.html
Braided brake hose is available from several different vendors, I went with Inline