I used to have a 72 Camaro with a 350. When I got it it was set up with large chambered angle plug heads and a 2bbl carb. It got around 17mpg.
I swapped the manifold for a Torker II & a 600 cfm Holley. It got aroung 15mpg.
I cracked one of the stock heads and put on a pair of small chambered 283 heads. It got around 15mpg.
I swapped the 283 heads for a pair of camel humps with 2.05/1.94 valves and mild pocket porting and lost the 600cfm for an all mechanical 780cfm Holley and added a set of Hookers -- it got around 13mpg but ran like a bat out of hades.
Bottom line is I never got back to the milage it was getting when I bought it stock.